Article added to library!
x
  • UK casinos not on GamStop
    • Pubchase is a service of protocols.io - free, open access, crowdsourced protocols repository. Explore protocols.
    Sign in
    Reset password
    or connect with
    Facebook
    By signing in you are agreeing to our
    Terms Of Service and Privacy Policy
  • See more
    • '); var ntfc_preview = ''; $.post('/api/v1/get_notifications', function(r) { var ntfc_read_pending = 0; var ntfc_pending = 0; $.each(r.notifications.pending, function(index, ntfc_object) { ntfc_read_pending++; ntfc_pending++; if (ntfc_read_pending
    ' + ntfc_object.full_name +'' + ntfc_object.time + '
    ' + ntfc_object.description +'
    '; }) if (ntfc_read_pending
    ' + ntfc_object.full_name +'' + ntfc_object.time + '
    ' + ntfc_object.description +'
    '; }) $('.notification-block .dropdown-menu').html(ntfc_preview); $('.notification-block .dropdown-menu').append('
  • See more
    • '); if (ntfc_pending > 0) { $('.notification-count').text(ntfc_pending).show(); } else { $('.notification-count').hide(); } } else { $('.notification-block .dropdown-menu').html(ntfc_preview); $('.notification-block .dropdown-menu').append('
  • See more
    • '); if (ntfc_pending > 0) { $('.notification-count').text(ntfc_pending).show(); } else { $('.notification-count').hide(); } } if (ntfc_read_pending == 0) { $('.notification-block .dropdown-menu').html('
  • You don\'t have any notifications
  • See more
    • '); $('.notification-count').hide(); } data = {'nid' : '', 'ntid' : 1}; $.post('/api/v1/notification_action', data, function(r) { if (r.request == 'OK') { $('.notification-count').hide(); } }); }, "json"); }); $('.search-save-box').on({ click : function(e) { e.preventDefault(); var search_attr = $(this).attr('rel').split(','); var p = search_attr[1]; var tf = search_attr[0]; window.location = '/search?tf='+tf+'&jc='+jc+'&keywords='+$(this).html()+'&s='+$('#sort_order').val()+'&p='+p; } }, '.search-name'); $( "#keywords_main, #keywords_mobile" ).focus(function(e) { show_saved_searches(e, $(this)); }); $(window).resize(function () { if ($('.search-save-box').is(':visible')) { if ($('#keywords_main').is(':visible')) var left_search_save = $('#keywords_main').offset().left; if ($('#keywords_mobile').is(':visible')) var left_search_save = $('#keywords_mobile').offset().left; $('.search-save-box').css('left',left_search_save); } }); $('.search-save-box').on({ click : function(e) { e.preventDefault(); delete_saved_search($(this)); } }, '.search-name-close'); $('.search-save-box, #keywords_main, #keywords_mobile').click(function(e) { e.stopPropagation(); }); $(document).click(function(e) { $('.search-save-box').hide(); }); $( "#keywords_main, #keywords_mobile" ).autocomplete({ source: function( request, response ) { // data contains the JSON object textStatus contains the status: success, error, etc $.post('/api/v1/searches', {'key' : request.term}, function(data, textStatus) { response(data); }, "json") }, select: function (event, ui) { var reportname = ui.item.value; var thelinks = '/search?tf='+$('#time_frame').val()+'&jc='+jc+'&keywords='+reportname+'&s='+$('#sort_order').val()+'&p='+$('#people_cluster').val(); } }); $('.search-go').click(function(e) { e.preventDefault(); window.location = get_search_url(); }); $('.logout').click(function(e) { e.preventDefault(); }); $('.header_keywords, .home_page_keywords').on('keydown', function(e) { if (e.keyCode == 13) { window.location = get_search_url(); } $('.search-save-box').hide(); }); $('.seemore').click(function(e){ e.stopImmediatePropagation(); }); });
    Add to Library
    Associating cellular epigenetic models with human phenotypes.
    May 30, 2017
    Nature Reviews. Genetics
    Lappalainen T, Greally JM
    Epigenetic association studies have been carried out to test the hypothesis that environmental perturbations trigger cellular reprogramming, with downstream effects on cellular function and phenotypes. There have now been numerous studies of the potential molecular mediators of epigenetic changes by epigenome-wide association studies (EWAS). However, a challenge for the field is the interpretation of the results obtained. We describe a second-generation EWAS approach, which focuses on the possible cellular models of epigenetic perturbations, studied by rigorous analysis and interpretation of genomic data. Thus refocused, epigenetics research aligns with the field of functional genomics to provide insights into environmental and genetic influences on phenotypic variation in humans.
      
    Add Public PDF
      
      
    Upload my PDF
      

    Downloading PDF to your library...

    ADD A TAG      64 chars max

      Make private

    APPLIED TAGS

    Uploading PDF...

    PDF uploading

    Delete tag:

    The link you entered does not seem to be valid

    Please make sure the link points to nature.com contains a valid shared_access_token