Article added to library!
x
Pubchase is a service of protocols.io - free, open access, crowdsourced protocols repository. Explore protocols.
Sign in
Reset password
or connect with
Facebook
By signing in you are agreeing to our
Terms Of Service and Privacy Policy
  • See more
  • '); var ntfc_preview = ''; $.post('/api/v1/get_notifications', function(r) { var ntfc_read_pending = 0; var ntfc_pending = 0; $.each(r.notifications.pending, function(index, ntfc_object) { ntfc_read_pending++; ntfc_pending++; if (ntfc_read_pending
    ' + ntfc_object.full_name +'' + ntfc_object.time + '
    ' + ntfc_object.description +'
    '; }) if (ntfc_read_pending
    ' + ntfc_object.full_name +'' + ntfc_object.time + '
    ' + ntfc_object.description +'
    '; }) $('.notification-block .dropdown-menu').html(ntfc_preview); $('.notification-block .dropdown-menu').append('
  • See more
  • '); if (ntfc_pending > 0) { $('.notification-count').text(ntfc_pending).show(); } else { $('.notification-count').hide(); } } else { $('.notification-block .dropdown-menu').html(ntfc_preview); $('.notification-block .dropdown-menu').append('
  • See more
  • '); if (ntfc_pending > 0) { $('.notification-count').text(ntfc_pending).show(); } else { $('.notification-count').hide(); } } if (ntfc_read_pending == 0) { $('.notification-block .dropdown-menu').html('
  • You don\'t have any notifications
  • See more
  • '); $('.notification-count').hide(); } data = {'nid' : '', 'ntid' : 1}; $.post('/api/v1/notification_action', data, function(r) { if (r.request == 'OK') { $('.notification-count').hide(); } }); }, "json"); }); $('.search-save-box').on({ click : function(e) { e.preventDefault(); var search_attr = $(this).attr('rel').split(','); var p = search_attr[1]; var tf = search_attr[0]; window.location = '/search?tf='+tf+'&jc='+jc+'&keywords='+$(this).html()+'&s='+$('#sort_order').val()+'&p='+p; } }, '.search-name'); $( "#keywords_main, #keywords_mobile" ).focus(function(e) { show_saved_searches(e, $(this)); }); $(window).resize(function () { if ($('.search-save-box').is(':visible')) { if ($('#keywords_main').is(':visible')) var left_search_save = $('#keywords_main').offset().left; if ($('#keywords_mobile').is(':visible')) var left_search_save = $('#keywords_mobile').offset().left; $('.search-save-box').css('left',left_search_save); } }); $('.search-save-box').on({ click : function(e) { e.preventDefault(); delete_saved_search($(this)); } }, '.search-name-close'); $('.search-save-box, #keywords_main, #keywords_mobile').click(function(e) { e.stopPropagation(); }); $(document).click(function(e) { $('.search-save-box').hide(); }); $( "#keywords_main, #keywords_mobile" ).autocomplete({ source: function( request, response ) { // data contains the JSON object textStatus contains the status: success, error, etc $.post('/api/v1/searches', {'key' : request.term}, function(data, textStatus) { response(data); }, "json") }, select: function (event, ui) { var reportname = ui.item.value; var thelinks = '/search?tf='+$('#time_frame').val()+'&jc='+jc+'&keywords='+reportname+'&s='+$('#sort_order').val()+'&p='+$('#people_cluster').val(); } }); $('.search-go').click(function(e) { e.preventDefault(); window.location = get_search_url(); }); $('.logout').click(function(e) { e.preventDefault(); }); $('.header_keywords, .home_page_keywords').on('keydown', function(e) { if (e.keyCode == 13) { window.location = get_search_url(); } $('.search-save-box').hide(); }); $('.seemore').click(function(e){ e.stopImmediatePropagation(); }); });
    Aug 01, 2013
    Nature Add nature.com free-link Cancel
    Variability of regenerative potential among animals has long perplexed biologists. On the basis of their exceptional regenerative abilities, planarians have become important models for understanding the molecular basis of regeneration. However, planarian species with limited regenerative abilities are also found. Despite the importance of understanding the differences between closely related, regenerating and non-regenerating organisms, few studies have focused on the evolutionary loss of regeneration, and the molecular mechanisms leading to such regenerative loss remain obscure. Here we examine Procotyla fluviatilis, a planarian with restricted ability to replace missing tissues, using next-generation sequencing to define the gene expression programs active in regeneration-permissive and regeneration-deficient tissues. We found that Wnt signalling is aberrantly activated in regeneration-deficient tissues. Notably, downregulation of canonical Wnt signalling in regeneration-deficient regions restores regenerative abilities: blastemas form and new heads regenerate in tissues that normally never regenerate. This work reveals that manipulating a single signalling pathway can reverse the evolutionary loss of regenerative potential.
      
    Add Public PDF
      
      
    Upload my PDF
      

    Downloading PDF to your library...

    ADD A TAG      64 chars max

      Make private

    APPLIED TAGS

    Uploading PDF...

    PDF uploading

    Delete tag:

    The link you entered does not seem to be valid

    Please make sure the link points to nature.com contains a valid shared_access_token